Abstract
Methylguanidine (MG) has been implicated as a potent uremic toxin1–3. Furthermore, the carcinogenecity of the nitrosated compound, MG, has been reported4. Chemically, MG is an oxidative product which results from the exposure of creatinine (CRN) to silver, mercury, copper, Fe3+ or charcoal5. However the factors affecting the oxidation of CRN to MG are far different from the internal environment of uremics, and the mechanism of its synthesis in vivo still remains unclear. We have reported MG synthesis in various tissues of rats and also have shown MG synthesis in liver using isolated hepatocytes6.
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