Active oxygen forms and antioxidant blood status in patients with community acquired pneumonia and its combination with COPD

Abstract

Disorders in free radical oxidation (FRO) may play an important role in community acquired pneumonia (CAP) developing in COPD patients. The aim was to study the production of active oxygen forms (AOF) and total anti-oxidant blood status (AOS) in patients with CAP and its combination&nbsp;&nbsp; with COPD <b>Methods:</b> The study included 32 patients hospitalized for CAP and 30 patients with combination of CAP and COPD. Generation of active oxygen forms (AOF) in the blood of patients was studied by registration of chemiluminescence (ChL). Total AOS in the patients9 blood serum has been determined by using TAS RANDOX. The control group comprised apparently healthy 30 individuals. <b>Results:</b> The values of prognostic CRB-65 scale and severity of the condition were higher in patients with combination of CAP and COPD compared to the patients with CAP. In patients under the study ChL of blood was decreased by 1.5 times. It indicated decreased production of AOF by blood cells. In patients with CAP total AOS of the blood was found to be increased. Conversely, in patients with combination of CAP and COPD AOS of blood was decreased. After treatment more marked clinical symptoms, higher level of C-reactive protein in serum, disturbances in the AOF production and lower AOS of blood were observed in patients with combination of CAP and COPD. <b>Conclusion:</b> In patients with combination of CAP and COPD compared to patients with CAP disorders in FRO were more marked and may be one of the risks of incomplete resolution of the inflammatory process.