Active oils, comparator oils, and study populations as explanations for contrasting results of reduce-it vs. strength: copenhagen general population study mimicking trial designs

Abstract

Background and Aims: We tested the hypothesis that conflicting results for the efficacy of high-dose, purified omega-3 fatty acids for prevention of atherosclerotic cardiovascular disease (ASCVD) in two randomized trials, REDUCE-IT and STRENGTH, can be explained by differences in active oil, comparator oil, and study population.