Abstract

Mice were given Candida albicans, C. tropicalis, C. guilliermondii or C. parapsilosis by different routes and subsequently challenged intravenously with either C. albicans, C. tropicalis or bacteria. In a minority of individual experiments, experience with Candida provided protection against challenge with homologous or heterologous strains and species of Candida but not against bacterial challenge. The most effective immunizing regimen was C. tropicalis given intravenously, protection being evidenced by delayed death, increased 28-day survival and reduced tissue Candida populations. These, as well as the studies of others, suggest that in the future it may be practicable and advisable to immunize certain individuals who are inordinately susceptible to candidiasis.

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