Abstract
Background: This study is on Acacia seyal gum, which is an exudate from Talha (Acacia seyal) tree. It provides a rich source of prebiotic that is used traditionally in folk medicine. Aims: The anti-proliferative effect (APE) of Acacia seyal gum (ASG) and Prebio-T-commercial (PTC) samples on human breast cancer (MCF-7) cell lines, and their antioxidant activities (AA) were investigated. Methods: The methanol crude extracts of both Acacia seyal gum and Prebio-T- commercial were fractioned into acetone and methanol, respectively. The anti-proliferative effect on human breast cancer cell lines for each fraction was examined using sulphorhodamine assay (SRB assay). Methanol crude extracts and their active compositions were analysed carefully using Gas chromatography-mass spectrometry technique.
Highlights
Breast adenocarcinoma (MCF-7) cell line is one of the most frequently diagnosed cancer in women globally
Results and Discussion a) Anti-proliferative effect of methanol extract of Acacia seyal gum Table 1 and Figure 2-3 present the results of the anti-proliferative effect (APE) for the methanol crude extract (MCE) Acacia seyal gum (ASG), and PTC samples and their active fractions against the human breast tumor MCF-7 cell lines
To the best of the Author's knowledge, this is the first time for the APE of Acacia seyal gum investigated using MCE on in vitro cell lines based
Summary
Breast adenocarcinoma (MCF-7) cell line is one of the most frequently diagnosed cancer in women globally. The World Health Organization (WHO) estimated that 84 million people would die from cancer between 2005 and 2015[2]. It constitutes a public severe health problem in both developed and developing countries. Current protocols of treatment include radiation therapy, surgical intervention, and chemotherapy, which induce numerous side effects such as nausea, fatigue, vomiting, weak of the immune system and hair loss. Treatment for breast cancer (BC) involveshormonal therapy, chemotherapy, surgical intervention, and radiotherapy. Exhaustive treatment with chemotherapy or radiotherapy is frequently related to few side effects ranging from the failure of bone marrow, fatigue, hair loss, vomiting, nausea, and weakness of the immune system[3]. Polyphenols from Acacia seyal gum (ASG) might be a potential anticancer agent in the future
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