Year-end Sale % OFF 
Abstract
SUMMARY Subcellular solubilized antigen derived from donor lymphocytes has been found to prolong canine renal allograft survival when administered i.v. before transplantation and when combined with postoperative azathioprine and methylprednisolone in small doses. The prolongation was found to be dependent upon the combination of the total dosage of antigen and the duration of pretreatment. In two groups of animals, significant prolongation was found to be associated with the presence of specific antidonor antibodies. In one other group, pretreated for only 2 weeks, survival was prolonged to a significant degree, but no antibodies were detected. Enhancement was the mechanism thought most likely to explain the data when antibody was present, but tolerance might have been achieved in one group of dogs. The pattern of antibody production was related to the duration of pretreatment, as well as to antigen dosage, and only cytotoxic antibody was measured. Cell-mediated immunity also was found to be related to these two factors, but it did not appear to play a key role in the prolongation of allograft survival.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
