Active control of plasma membrane composition regulates membrane protein signalling

Abstract

The cell surface interfaces with the external milieu constantly decoding signals in the form of chemical and physical cues, interpreted primarily by membrane receptors. These receptors are embedded in the plasma membrane where laterally segregated domains play pivotal roles in these signalling processes. One example of such a domain is the ensemble of transient nanoscale clusters of the peripheral GPI-anchored proteins which are templated by the active mechanics of acto-myosin at the inner leaflet of the cell membrane.