Abstract
Abstract A series of novel α-peptide ribonucleic acid (αPRNA) oligomers, possessing alternative αPRNA–Gly/Lys sequences, were newly designed, synthesized, and evaluated as the second-generation PRNA. As expected, the αPRNA with Lys formed stable sequence-specific complex with the complementary DNA, for which both the hydrogen-bonding interactions between the complementary nucleobase pairs and the electrostatic interactions between the ammonium cation on the lysine side chain and the DNA phosphate anion on the backbone are jointly responsible.
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