Active components of anti-adhesion therapy based on titanium nanoparticles

Abstract

Introduction. The adhesion process of the abdominal cavity is a complex of body reactions in response to inflammatory processes in the abdominal cavity, trauma of the mesothelium during surgical interventions. Adhesive intestinal obstruction in children of the Sverdlovsk region remains significant in the structure of acquired intestinal obstruction. The actual direction in the treatment of adhesions in children is the use of nanoparticles of titanium glycerosolvate aquacomplex in combination with Lydase 128 U. Purpose of the study is to evaluate the results of treatment of adhesive intestinal obstruction in children of the Sverdlovsk region using the aqua-complex of titanium glycerosolvate with lidaza 128 U. Materials and methods. A retrospective analysis of the case histories of children treated in the emergency surgery department of the City Children's Clinical Hospital № 9 of Yekaterinburg from 2013 to 2018 was conducted. The total number of cases n = 92. All children were divided into groups depending on the disease that caused the obstruction. Results. When a commissural obstruction was suspected, all children were prescribed conservative therapy, which was successful in 41,3% of cases. In the absence of positive dynamics of conservative treatment, surgical treatment is indicated. Laparoscopy was performed in 28 of children and was successful in half the cases. Laparotomy was performed when it was impossible to eliminate obstruction with the minimally invasive method. The postoperative period proceeded without surgical complications with the use of anti-adhesion therapy using nanoparticles of the aqua-complex of titanium glycerosolvate in combination with lydasum 128 U. Conclusions . The multifactorial development of the adhesive process leads to the formation of adhesions. The choice of surgical treatment depends on the severity of adhesions. The use of the gel combination Tizol with lydasum 128 U is a modern method of anti-adhesive therapy in medicine.