Activation of vanilloid (VR1) receptors by capsaicin stimulates release of brain derived neurotrophic factor from enteric sensory neurons

Abstract

0.2 (p<0.01). The contraction amplitude was not changed. Mean plasma GLP-1 was 87.6 +/-10.4 and 129.3 + / 6 7 pmolFL, respectively. In patients with IBS, GLP-1 1.2 pmolflag/ rain reduced the MMCs and reduced the contraction frequency from 1.6 +/-0.2 to 1.0 + / 02 per rain (p<:0.05) and motility index from 4.8 +/-0.1 to 4.1 +/-0.3 Ln ~(mmHg * s/rain) (p<0.21); GLP-I 2.5 pmol/kg/min reduced the MMCs and the contraction frequency from 1.7 +/-0.2 to 10 +/-0.2 per rain (p<0.01) and the motility index from 5.1 +/-0.2 to 4.0 + A 0 4 (p<0.01) at the same recording point with no effect on the contraction amplitude. Motility recordings from the antrum and duodenum displayed a similar change with GLP-1. Mean plasma concentration was 91.7 +/-22.6 and 176.1 +/-28.2 pmol/L, respectively. During infusion with GLP-1 plasma levels of PYY were reduced while plasma levels of GLP-2 were unchanged compared to saline CONCLUSION: GLP-1 reduces motility in the antroduodenal region and inhibits the MMC in healthy subjects and IBS patients. Thus, GLP-1 may alleviate symptoms in patients with motility-related gastrointestinal pain or discomfort.