Abstract
Experiment 1 showed that intravenous administration of veratrine resulted in inhibition of the tail-flick reflex, bradycardia, and hypotension. These antinociceptive and cardiovascular actions of veratrine were unaffected by pretreatment with iv administration of.5 mg/kg of the opioid-receptor antagonist naloxone. Experiment 2 demonstrated that veratrine-induced inhibition of the tail-flick reflex was eliminated by bilateral cervical vagotomy in an anesthetized rat preparation, but was unaffected by either a unilateral right or left vagotomy in a conscious rat preparation. Experiment 3 showed that intravenous administration of veratrine resulted in inhibition of the paw-lick response to painful thermal heat and that this antinociceptive action of veratrine was unaffected by pretreatment with systemic administration of 20 mg/kg naloxone. These experiments show that veratrine-induced antinociception is mediated by peripheral activation of vagal afferents.
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