Abstract
Two strains of transgenic (Tg) mice (Vα2.3/Vβ8.2 and Vα4/Vβ8.2) have T cell receptors (TCR) that recognize the NAc1-11 immunodominant epitope of the myelin basic protein (MBP). Spontaneous experimental autoimmune encephalomyelitis (sEAE) readily develops in Vα2.3/Vβ8.2 mice. T cells in Vα2.3/Vβ8.2 mice demonstrate increased levels of CD69, CD44 high and decreased CD45RB relative to Vα4/Vβ8.2 mice. Increased proliferative responses to MBP and high levels of TNF-α are seen in Vα2.3/Vβ8.2 mice. High IL-4 and TGF-β production is observed in Vα4/Vβ8.2 mice. CC chemokines (macrophage inflammatory protein-1 α (MIP-1α), RANTES and monocyte chemotactic protein 1 (MCP-1)) are increased in the central nervous system (CNS) of Vα2.3/Vβ8.2 mice. Thus, activated Th1 cells in the periphery of Vα2.3/Vβ8.2 mice may traffic to the CNS in response to CC chemokines, influencing sEAE.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
