Activation of the mechanosensitive ion channel PIEZO1/2 by YODA1 modulates cellular functions of human oa chondrocytes

Abstract

Purpose: Piezo proteins represent large membrane proteins that form mechanically activated Ca2+-permeable non-selective cationic channels. As a mechanosensitive ion channel Piezo functions as a sensor for membrane tension and transduces these forces into biological effects. The channel protein is further known to be critical for endothelial shear stress-sensing and vascular development. In articular cartilage, chondrocytes react to mechanical stimulation, while mechanical stress can affect the chondrocyte phenotype by altering the expression of chondrocyte extracellular matrix.