Activation of the AhR pathway prevents food allergy in mice

Abstract

Ovalbumin treatment resulted in a huge influx of leukocytes in the BAL fluid. Treatment with scGOS/lcFOS/pAOS showed a decreasing trend in the total number of leukocytes in the BAL fluid, represented by decreases in the number of macrophages, neutrophils, eosinophils and lymphocyte subsets. Airway hyperresponsiveness was increased in ovalbumin treated animals. However, treatment with scGOS/lcFOS/pAOS did neither suppress the airway hyperresponsiveness nor airway remodeling. Thesefindings suggest that scGOS/lcFOS/pAOSmighthaveapreventive effect on the allergic influxof immunecells found in chronic asthma,however, themodelweusedmightbe toosevere toobserve differences in lung remodeling parameters. These data encouraged us to further investigate theeffects of scGOS/lcFOS/pAOS inamilder chronic asthma model.