Abstract
Our laboratory is interested in developing methods that allow expression of exogenous genes in skin for therapeutic purposes (skin gene therapy). One approach involves direct introduction of genetic material by intradermal (ID) injection of naked plasmid DNA [15, 28]. Following ID injection of plasmid DNA, the encoded proteins are transiently and predominantly expressed in keratinocytes in a dose-dependent manner. Gene expression in other skin cells [including dendritic cells (DC), fibroblasts and adipocytes] has also been observed after injection of plasmid DNA into skin [16].
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