Abstract
Some CD2 family receptors stimulate NK cell-mediated cytotoxicity through a signaling pathway, which is dependent on the recruitment of an adapter protein called SLAM-associated protein (SAP). In this work we identify a novel leukocyte cell surface receptor of the CD2 family called CD2-like receptor activating cytotoxic cells (CRACC). CRACC is expressed on cytotoxic lymphocytes, activated B cells, and mature dendritic cells, and activates NK cell-mediated cytotoxicity. Remarkably, although CRACC displays cytoplasmic motifs similar to those recruiting SAP, CRACC-mediated cytotoxicity occurs in the absence of SAP and requires activation of extracellular signal-regulated kinases-1/2. Thus, CRACC is a unique CD2-like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway.
Highlights
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CD2-like receptor activating cytotoxic cells (CRACC) cDNA was amplified by RT-PCR from human NK cells and CD8ϩ T cells
Our study identifies CRACC as a cell surface glycoprotein of the CD2 family, which activates NK cell-mediated cytotoxicity through an extracellular signal-regulated kinase (ERK)-mediated pathway which is SLAM-associated protein (SAP)-independent
Summary
Cutting Edge: Activation of NK Cell-Mediated Cytotoxicity by a SAP-Independent Receptor of the CD2 Family1 Some CD2 family receptors stimulate NK cell-mediated cytotoxicity through a signaling pathway, which is dependent on the recruitment of an adapter protein called SLAM-associated protein (SAP). CRACC is a unique CD2like receptor which mediates NK cell activation through a SAP-independent extracellular signal-regulated kinase-mediated pathway.
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