Abstract
Activation of nitric oxide (NO)-synthesizing neurones in the hypothalamus and brain stem was studied during naloxone-precipitated morphine withdrawal in rats. In animals that underwent behavioural changes consistent with withdrawal, Fos and nicotinamide dinucleotide phosphate-diaphorase (NADPH-D)-positive neurones were identified within the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei as well as the brain stem nucleus tractus solitarius (NTS). A larger proportion of NADPH-D-positive neurones were activated in the PVN than in the NTS. While NO has been implicated in the genesis of opioid withdrawal, the present data provide evidence for the activation of select populations of NO-synthesizing neurones during the opiate withdrawal syndrome.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
