Abstract
Muscarinic K + channels (I K(ACh)) in native atrial myocytes are activated by βγ subunits of pertussis toxin (Ptx)-sensitive heterotrimeric G proteins coupled to different receptors. βγ subunits of Ptx-insensitive G s, coupled to β-adrenergic receptors, do not activate native I K(ACh). In atrial myocytes from adult rats transfected with rat brain β 1 subunit I K(ACh) can be activated by stimulation of β-adrenergic receptors using isoprenaline. This effect is insensitive to Ptx. These findings demonstrate for the first time promiscuous (Ptx-insensitive) coupling of G sβγ to GIRK channels in their native environment.
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