Abstract
The goal of the present study was to evaluate the influence of staphylococcal lipoteichoic acid (LTA) on the activation of mononuclear immune cells. A murine tumor necrosis-like factor (TNF-like) was induced in the sera of CD-1 mice which had been primed with heat/formalin-inactivated Propionibacterium avidum KP-40 and subsequently exposed to LTA extracted from Staphylococcus saprophyticus strain S 1. Monoclonal antibody against murine TNF (anti-TNF) significantly inhibited the cytostatic activity of mice sera against transformed L-929 cells. Freshly isolated lymphocytes did not display interleukin 2 (Il-2) receptors, but receptors were expressed on Con A incubated cells and in significantly higher numbers after coexposure to staphylococcal LTA in vitro. Since the induction of TNF (macrophages) and Il-2 receptors (lymphocytes) represent stimulation of the mononuclear immune system, staphylococcal LTA may be considered to be an immunomodifier.
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