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Abstract
Activation of microglia bolsters synapse formation.
Highlights
Edited by: Raquel Ferreira, University of Southern California, USA Reviewed by: Tiago Santos, University of Beira Interior, Portugal †These authors have contributed to this work
Microglial cells in the central nervous system (CNS) are major players of innate immunity, the first line of defense in the presence of danger signals, from bacterial infections to mediators released by neurons upon cytotoxic insult (Kettenmann et al, 2011)
The role of microglia has been mostly approached from the angle of pathology, microglial cells are active players in healthy conditions by constantly monitoring the brain parenchyma (Davalos et al, 2005; Nimmerjahn et al, 2005) and correcting deviations from homeostasis; several studies reported that the genetic alteration of molecules selectively blunting specific microglial functions impacted on synaptic transmission and synaptic plasticity (Pascual et al, 2012; Ji et al, 2013; Zhang et al, 2014), leading to deficits of behavioral response, such as social interaction, motor learning, or short-term memory (Rogers et al, 2011; Parkhurst et al, 2013; Zhan et al, 2014)
Summary
Edited by: Raquel Ferreira, University of Southern California, USA Reviewed by: Tiago Santos, University of Beira Interior, Portugal †These authors have contributed to this work. Brain inflammation induces postsynaptic changes during early synapse formation in adult-born hippocampal neurons by Chugh, D., Nilsson, P., Afjei, S.
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