Abstract
In experimental models of adult brain injury metalloproteinase‐2 and ‐9 (MMPs) are up‐regulated and may play critical role in the pathophysiology of neuronal degeneration. Accordingly, the aim of this study was to evaluate the temporal pattern of MMPs activation following hypoxia‐ischemia (HI) during the early postnatal weeks, when the brain exhibits elevated levels of plasticity and neuroprotection. Alterations in MMPs were assessed over the course of 2 weeks after the insult. Our results show that HI induced in 7‐day‐old rats leads to a fast increase of MMPs activity in ipsilateral hemisphere, with maximum level within the first 48 h after injury. It was much more pronounced in the case of MMP‐9. After the transient decrease at 72 h after HI, the MMPs activity remained elevated again for up to 14 days. This study suggests an involvement of metalloproteinases in the development of immature brain injury after HI.
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