Abstract
A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.
Highlights
IntroductionSynthetic erythropoietic drugs EPO, Epogen (epoetin alfa), Procrit (r-HuEPO), Mircera (methoxyethylene glycolepoetin beta), and Aranesp (darbepoietin alfa) are used to stimulate red blood cell (RBC) production in the bone marrow, thereby correcting anemia, minimizing the need for transfusion requirements, and improving the quality of life for patients [1]
Synthetic erythropoietic drugs EPO, Epogen, Procrit (r-HuEPO), Mircera, and Aranesp are used to stimulate red blood cell (RBC) production in the bone marrow, thereby correcting anemia, minimizing the need for transfusion requirements, and improving the quality of life for patients [1]
Synthetic leukopoiesis-stimulating drugs are divided into low molecular weight and high molecular weight compounds
Summary
Synthetic erythropoietic drugs EPO, Epogen (epoetin alfa), Procrit (r-HuEPO), Mircera (methoxyethylene glycolepoetin beta), and Aranesp (darbepoietin alfa) are used to stimulate red blood cell (RBC) production in the bone marrow, thereby correcting anemia, minimizing the need for transfusion requirements, and improving the quality of life for patients [1]. Synthetic leukopoiesis-stimulating drugs are divided into low molecular weight and high molecular weight compounds. Low molecular weight synthetic compounds include levamisole ((S)-2,3,5,6-tetrahydro-5-phenylimidazo [2,1-b] thiazole), dibazole (2- (phenylmethyl)1H-benzimidazole), methyluracil (dioxymethyltetrahydropyrimidine), pentoxyl (5-hydroxymethyl-4-methyluracil), diuciphone (diaminodiphenylsulfone with methyluracil), galavit (phthalhydroside derivative), glutoxim (Bis-(c-L-glutamyl)-L-cysteine-bis-glycine-disodium salt), and others [2]. High molecular weight compounds include polyoxidonium (a derivative of polyethylene piperazine). They accelerate the reproduction and growth of cells, restore the mass and function of damaged organs and tissues, activate leukopoiesis, and increase leukocyte activity. Acting on B-lymphocytes, pyrimidines increase the activity of Krebs cycle enzymes, stimulate their conversion into plasma cells producing immunoglobulins, promote the formation of antibodies, lysozyme, complement, properdine, and interferon, increase the absorption activity of neutrophils and macrophages, affect the body’s immune activity, and have anti-inflammatory act [3]
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