Abstract
Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. To map changes in theKP induced by infant CPB. Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.
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