Abstract
Prostaglandin effects on the heart include changes in the functional and metabolic state, as well as a reduction of ischemia-induced myocardial injury1 and arrhythmias2. The cellular targets of these effects, however, have not been unambiguously defined. Since prostaglandins act via G protein coupled receptors, it is likely that cardiac tissues express one or several of the five classes of prostaglandin receptors, i. e. EP, IP, DP, FP and TP receptors. We here report a direct inhibitory action of PGE1 on myocardial contractility during β-adrenergic inotropic stimulation, that is likely to be mediated by an E-type prostaglandin receptor (EP3 subtype) leading to inhibition of adenylate cyclase.KeywordsLeft Anterior DescendIschemic Myocardial InjuryReceptor Selective AgonistDirect Inhibitory ActionCardiac SarcolemmaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
