Abstract
Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or γ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl4) hepatopathy. Moreover, radon inhalation also inhibits CCl4-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.
Highlights
Takahiro Kataoka and Kiyonori YamaokaGraduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan
We describe the activation of biodefense system by low-dose X- or γ-irradiation or radon inhalation and its applicable possibility for treatment of diabetes and nonalcoholic liver disease
In the control groups not treated with alloxan, the superoxide dismutase (SOD) activities in pancreas significantly increase in the 0.5 or 1.0 Gy irradiation groups compared with sham-irradiated control group
Summary
Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation. Glutathione directly reacts with reactive oxygen species (ROS), and GPx catalyzes the destruction of H2O2 and hydroxyl radical (OH). This catalysis generates oxidized glutathione (GSSG) and reduced glutathione (GSH) We describe the activation of biodefense system by low-dose X- or γ-irradiation or radon inhalation and its applicable possibility for treatment of diabetes and nonalcoholic liver disease
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