Abstract
The functional relevance of CD2-mediated signal transduction in triggering T cell receptor/CD3-independent natural killer cell cytotoxicity was investigated by introducing wild-type CD2 or signaling-deficient CD2 with truncated cytoplasmic region into a murine natural killer-like large granular lymphocyte clone lacking CD2 and T cell receptor/CD3. The introduction of wild-type CD2 led to CD2-dependent binding and cytotoxicity against P815 target cells. In contrast, the introduction of mutant CD2 with truncated cytoplasmic region led to comparable P815 binding but reduced cytotoxicity as compared with the wild type. These results provide a direct evidence for CD2-mediated triggering of NK cell cytotoxicity upon target cell binding.
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