Abstract
AbstractThe goal of this work was to determine the reaction mechanism for Pseudomonas species lipase activation by cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride based on the results from enzyme kinetics. These drugs are the essential activators of Pseudomonas species lipase in the presence of triton‐X 100 or taurochloate in vitro. Moreover, QSAR studies show that the pKA values are correlated with the molecular weights of these drugs.
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