Activation, Inhibition and Reversal of Inhibition of Plasma Volume Changes in Adrenalectomized and Intact Dogs.

Abstract

SummaryAdenosine triphosphate raises the plasma volume of dogs possessing adrenal cortices but is without effect in 100 mg doses on the plasma volume of dogs lacking these glands. The negative action of adenosine triphosphate and also that of small (25 mg) ineffective doses of prednisolone per se upon the plasma volume of adrenalectomized dogs when injected singly, becomes highly positive when the two are administered together. These induced elevations of plasma volume in either type of test animal are completely inhibited by G-strophanthin and calcium. Prompt reversal of the inhibition follows administration of salts of K, Mg and Na and is accompanied by sharp increase in plasma volume.