Abstract
AbstractThe electrophilic activation of 2H‐azirines with triflic anhydride (Tf2O) for an addition/cyclization reaction producing 2‐aryl‐pyrido[2,3‐b]pyrazines regioselectively is described. This reaction proceeds via nucleophilic addition of 3‐amino‐2‐fluoropyridines onto 1‐trifloyl‐aziridin‐2‐yl triflates and subsequent cyclization via SNAr. Desulfonylation and oxidation provides a single regioisomer of the aza‐bicyclic heterocycle after treatment with Et3N. Optimization of the reaction conditions lead to a range of 2‐aryl‐pyrido[2,3‐b]pyrazines in isolated yields of 20 % to 60 %.
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