ACTIVATING EFFECT CF PHOTO-METRAZOL ON THE EEG OF VARIOUS PSYCHOSES AND NEUROSES CASES

Abstract

Summary PHOMAC was given to 176 psychoses and neuroses cases and clinical as well as biological investigation was set. The reactions to PHOMAC were classified into three types, namely, myoclonic response, convulsive response. and mixed response. Patients of manic depressive psychosis. neurosis, psychogenic reaction (hysteria), chronic alcoholism, and normal persons were found to show myoclonic responses only and patients of atypical endozenous pzychosis, psychopathy. and schizophrenia showed either myoclonic response or convulsive response, of which typical schizophrenia responded with the former only while epileptics showed all the three types. Convulsive response tendes to appear in cpileptics and those in whom epileptic factors could be suspected clinico-symptonatologically or in some other respects. Of schizophrenics, the group belonging to catatonic type gave evidently lower myoclonic threshold values than the other types. To compare the myoclonic threshold of each setting and with the same of normal persons as criterion, the cases of catatonia, chunk alcoholism, psychopithy, atypiczal endogenous psychosis and epilepsy showed low threshold values, while those of schizophrenia (excluding catatonia), manic depressive psychosis and neurosis returned high threshold values and psychogenic reaction cases (hysteria:) proved no significant disparity. in their values from normal persons. With the improvement of the clinical manifestations, the myoclonic threshold values of schizophrenics went lowered, whereas those of epileptics and endogenous psychosis upward. No such fluctuation was delectable with manic depressive psychotics, neurotics and the patients of psychogenic reaction (hysteria). As to the myoclonic threshold values of the cases of psychoses and neuroses represented by schizophrenia and manic depressive psychosis, the values were lower in those under 20 yrs of age than in those above it. The same availed in those with higher basal metabolism than in those with normal or lowered basal metabolic rate, again, in those showing abnormal E. E. G. under resting state with closed eyes than in those showing normal E. E. G., further, in slender persons than in fat and stout persons and, in those in states of lower vagotonic activation than those in higher vagotonic activation, respectively. Any sex difference was hardly observable concerning variance in threshold value.