Abstract
Effectiveness of donepezil in slowing the rate of cognitive decline in Alzheimer's disease (AD) has been established. Psychosocial interventions, such as reminiscence therapy and art therapy, are also known to have some clinical effects. However, combined effect of donepezil and psychosocial interventions on cerebral glucose metabolism has not been investigated. A case study using (18F) fluorodeoxyglucose and positron emission tomography revealed that cerebral glucose metabolism in the thalamus and fronto-subcortical network was stimulated after the combined intervention. These areas are considered not to be severely affected by pathological changes in AD. The comprehensive approach of donepezil and psychosocial interventions was judged to be effective for AD patients.
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