Abstract
In order to detect activated T lymphocytes in the cerebrospinal fluid (CSF) of patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied CSF lymphocytes in untreated patients with HAM/TSP and other neurological diseases (OND). Dual-immunofluorescence staining technique was performed using fluorescence microscopy. No significant difference in the CD4 +/CD8 + ratio of CSF lymphocytes was observed between HAM/TSP patients and patients with OND. However, both CD4 + and CD8 + CSF lymphocytes of HAM/TSP patients contained higher percentages of HLA-DR-positive cells than those of patients with OND ( P < 0.05). suggesting that the activated CSF T lymphocytes were composed of both CD4 + and CD8 + subsets in patients with HAM/TSP.
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