Abstract
The actions of zinc on A-type potassium current (I A) were studied in dissociated bullfrog sympathetic neurons. Zinc (1–300 μM) caused a parallel shift in the activation and inactivation curves to a depolarizing direction, thereby enhancing I A around physiological resting potential. An EC 50 value was 70–100 μM for these actions. The zinc actions were non-selective in a sense that zinc inhibited M-type potassium current (I M) with an IC 50 value of 300 μM. Zinc was without effect on the maximum conductance for I A and the kinetic behavior for I M. The ability of low concentrations of zinc to modulate separate set of potassium currents such as I A and I M in conceptually distinct manner may therefore assume pathophysiological importance for autonomic neurons.
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