Abstract
The actions of the beta-sympathomimetic bronchodilator trimetaquinol (TMQ) were examined on bovine pulmonary vein smooth muscle in vitro. TMQ partially and reversibly inhibited 5-hydroxytryptamine (5HT) induced contractions of the vein strips. The relaxant activity was neither blocked by propranolol (10(-7) M) nor enhanced by phentolamine (10(-7) M). Isoproterenol, alone or in the presence of phentolamine (10(-7) M), was much less effective than TMQ in relaxing 5HT-induced contractions. From these results it is suggested that TMQ functions via a "non-beta-adrenergic" mechanism to relax bovine pulmonary vein smooth muscle.
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