Abstract
Lidoflazine, 2.0 × 10 −5−1.2 × 10 −4M, was tested on the twitch responses elicited by direct and indirect stimulation of the isolated rat diaphragm. The drug produced a marked depression of the responses to indirect stimulation. Recovery from lidoflazine-induced depression was prolonged and sometimes incomplete. Neostigmine failed to reverse lidoflazine-induced neuromascular blockade except when blockade was slight. In indirectly stimulated chick biventer cervicis muscle, lidoflazine induced a depression of the twitch response followed by a contracture of the muscle. The characteristics of the neuromascular action of lidoflazine differ from those of the classical neuromascular blocking agents.
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