Actions of Interleukin-1β and Interleukin-4 on Blood Albumin Parameters in Rats with Different Behavioral Activities

Abstract

We report here a comparison of the effects of the pro-inflammatory cytokine interleukin-1β and the anti-inflammatory cytokine interleukin-4 on measures of blood albumin in rats with different types of behavioral activity in the open field. In the initial state, the total serum albumin concentration in active animals was significantly lower than that in passive individuals. However, the ratio of the effective albumin concentration to the total albumin concentration, which reflects its binding capacity, was greater in passive rats. Administration of interleukins led to decreases in the total and effective albumin concentrations in the blood of passive and especially active rats. There were no differences in the values of these parameters in animals with different types of behavioral activity after injections of interleukin-1β or interleukin-4. The initial intergroup differences in the binding capacity of serum albumin molecules were not seen after injections of these immunomodulators, because of the greater increase in this parameter in active individuals. These data indicate that interleukin-1β and interleukin-4 had differently directed effects on the properties of blood albumin binding centers in rats with different behavioral characteristics. The more marked effects of these cytokines on blood albumin parameters in behaviorally active rats than in passive individuals was linked with differences in the total albumin concentrations seen in these groups of animals in the initial state.