Abstract
Using an intraluminal pressure recording technique, we studied the actions of cholecystokinin and secretin on the motor activity of the upper small intestine in 24 healthy subjects. We showed that the “basal” motor activity of duodenum and jejunum was stimulated by cholecystokinin (CCK). In doses of 1, 2, and 4 U per kg per hr, CCK stimulated the nonrhythmic type I waves. Secretin, on the other hand, inhibited the nonrhythmic type I and type III waves. The interactions of these two hormones showed that the CCK-stimulated upper intestinal motility was inhibited by secretin, and that the secretininhibited motility was stimulated by CCK. This study indicates that both CCK and secretin can play an important role on the autoregulation of intestinal motor function in man.
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