Abstract
1. 1. The rates of integument penetration of benzodiazepines (BZDs) and their levels inside the body were determined in houseflies treated topically at a dose of 10 μg/fly. 2. 2. Concentrations of various BZDs in hemolymph were relatively associated with their biological activities against the housefly. 3. 3. Concentrations of BZDs detected inside the body were higher than the concentrations required to inhibit specific binding of tritiated BZDs to thorax-abdomen homogenates. 4. 4. Biological effects of BZDs appear to be secondary effects even if they are caused by an action on the thorax-abdomen binding sites.
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