Abstract
Axonless horizontal cells were enzymatically dissociated from the retinae of adult rabbits. Whole-cell patch-clamp recordings were made on dissociated cells and voltage- and ligand-induced currents were studied. When membrane potential was measured in the current-clamp configuration, current pulses injected into the cell induced repetitive action potentials. When the cells were depolarised by bath application of kainic acid (KA, 30μM), a train of fast-repetitive action potential was evoked. Also, a slow long-lasting calcium action potential kept the cells depolarised long after the cessation of the KA application. These findings indicate for the first time that horizontal cells of the mammalian retina are able to produce trains of action potentials.
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