Abstract
SummaryExperiments on thyroidectomized rats indicate that the formation of vacuolized “thyroidectomy cells” in the pituitary is prevented by daily doses of 50 γ of estradiol or ethinyl estradiol but remains unmodified by as much as 10 mg a day of testosterone, an-drostenediol, dehydro-iso-androsterone, preg-nanediol, pregnanedione, progesterone, des-oxycorticosterone acetate, pregnenolone or ethinyl testosterone. Unlike the formation of “castration cells” the development of “thyroidectomy cells” is hence not inhibitable by all hormonally active steroids even if they are administered in these comparatively high dosages.
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