Abstract
Experiments on rats indicate that pretreatment with thyroxine or calcitonin inhibits the soft-tissue calcification and the osteitis fibrosa induced by parathyroid extract overdosage. When the hormones are administered concurrently there is a summation of their actions. Calcitonin but not thyroxine inhibitits the skin calcification (calcergy) induced by an intravenous injection of lead acetate followed by topical administration of polymyxin. Moreover, calcitonin diminishes the hypercalcemia produced by a single injection of lead acetate, whereas thyroxine is ineffective in this respect. The mechanism of action of both hormones is briefly discussed.
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