Abstract
The physical properties of DNA after reaction with 7-bromomethylbenz[a]anthracene have been examined. Covalent binding of up to one hydrocarbon residue for 10 nucleotides does not cause denaturation, even locally, of the DNA. Equal numbers of adenine and guanine residues are substituted. Reactivity of DNA is greater than that of polyribonucleotide complexes. Fluorescence characteristics, particularly polarisation of fluorescence, of the carcinogen at levels of between 1 to 800 and 1 to 10 nucleotides in the DNA double helix are described and energy transfer discussed. A geometrical arrangement of the methylbenz[a]anthracene residues, in which the axis of the molecule lies in the large groove of the DNA double helix is proposed.
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