Abstract
The secretion of exotoxins by staphylococci pathogenic for man has been well known for many years, but only recently have the mechanisms of staphylococcal exotoxic injury received much study at the cellular level. The classical staphylococcal toxin, which causes dermonecrosis on injection into the skin of rabbits and is rapidly lethal after intravenous injection, has been purified in several laboratories and found identical with alpha lysin, as tested by lysis of rabbit erythrocytes (Kumar et al, 1962; Madoff and Weinstein, 1962; Bernheimer and Schwartz, 1963; Goshi et al, 1963; Jackson, 1963; Lominski et al, 1963). One alpha lysin preparation has been shown to induce prompt injury in cultured rabbit kidney and mouse ascites tumor cells, manifested by release of herpes virus from experimentally infected kidney cells and by marked swelling and release of S35 -L-methionme (both free and protein-bound) from kidney
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