Abstract
IT is now almost 100 years since sodium salicylate was first introduced into medicine as an antipyretic and an anti-inflammatory agent for the treatment of rheumatic fever. The salicylates are now among the most widely used and abundantly consumed of all drugs. Many proprietary analgesic compounds also contain some salicylate perhaps to ensure a therapeutic effect. Despite their wide use and a better understanding of the metabolism of salicylates in man,1 the mechanisms whereby salicylates produce such diverse effects as analgesia, reduction of fever, increase in respiration and suppression of inflammation in connective tissue are not understood. Out of the . . .
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