Abstract
In experiments on the internal carotid artery of a dog isolated from the rest of the circulation, the following effects of prostaglandins (PG) E1 and E2 were discovered. PG E1 caused either a constrictor or a dilator effect with habituation during repeated exposures, whereas PG E2 had only a constrictor effect without any habituation. The duration of the effects of PG E2, especially relaxation, was much longer than that of the effects of serotonin; residual contraction of the vascular smooth muscles was frequently observed; PG E1 and PG E2 potentiated the effects of serotonin and often of noradrenalin.
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