Abstract
The effect of age on potassium (K +)-induced norepinephrine release in the heart was studied in 6- and 24-month-old male Fischer-344 rats. Isolated hearts were perfused with Krebs-Ringer solution according to Langendorff method. K + was employed as 2 ml bolus at the concentrtions of 70, 90, 100 and 120 μM. Norepinephrine content was measured by high pressure liquid-chromatography/electrochemical detection methodology. At each of the K − concentrations, the amount of norepinephrine released from preparations of 6-month-old animals was significantly greater than observed from preparations of 24-month-old animals. Since K +-induced release of norepinephrine is associated with calcium influx, the decrease in the capacity of K + to cause norepinephrine release with age supports the hypothesis that diminution in transmitter release is due to altered calcium function.
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