Abstract
Polyene macrolide antibiotics are known to exhibit biological activity against fungi and other eukarytic organisms, but not against bacteria These antibiotics cause permeability alterations in sensitive cells which lead to the loss of cytoplasmatic constituents culminating in cell death. The selective toxicity of polyene antibiotics is due to interaction with a unique component, a sterol, in the membranes of sensitive organisms. The natural resistance of bacteria on the other hand is generally explained by the absence of sterols in the bacterial cell membranes. In contrast to results of other investigators we found a real antibacterial activity with several polyene antibiotics by using the stable protoplast type L-form of E. coli W1655F+ as a test organism.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
