Abstract
Platelet-rich plasma (PRP) is prepared by using autologous blood plasma enriched with platelet. PRP has been proven to be a successful analog to correct blood loss during cardiac surgery and cardiothoracic bypass. Some authors have demonstrated bone regeneration following tooth extraction with healthy compact bone by using PRP. Typical protocols include either 1 or 2 centrifugation steps to separate whole blood into 3 layers: a top plasma layer, middle leukocyte layer, and bottom red blood cell layer, to collect a concentrate of platelets in plasma. The rationale for use and therapeutic potential of a high concentration of platelets is based on their capacity to supply and release supraphysiologic amounts of essential growth factors and cytokines from their alpha-granules to provide a regenerative stimulus that augments healing and promotes repair in tissues with low healing potential.
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