Abstract
THE OBSERVATION THAT the heart rate of the thyroidectomised rat is not equally accelerated after feeding quantities of thyroid material having equal metabolic potency was first made when the action of commercial dried thyroid substance was compared with that of a purifiedthyroid-globulin fraction (1). The former material produced a heart rate approaching or exceeding that of the normal animal at metabolic responses which remained below the level of the normal rat, whereas the reverse was found when the thyroid globulin was used. Subsequent investigations showed that thyroids from normal animals (pig, rabbit, rat, and man) behave essentially like the thyroid-globulin, but that hyperplastic thyroids obtained by surgery from patients with Grave's disease have an effect similar to that of the commercial thyroid substance (2). Only one hyperplastic thyroid had been available from a patient who had not been treated with iodine preceding operation, and as that gland had little effect on the heart rate, the quest...
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