Abstract
Inotropic effect of Ni2+ on mitochondrial oxidative reactions were studied on myocardium preparations excised from the left frog ventricle and the rat heart mitochondria (RHM), respectively. In the presence of 10–200 μM Ni2+, the cardiac contraction amplitude increased in the dose-dependent manner. It has been found that Ni2+ is not toxic for RHM. The state 4 by Chance in the KCl medium was stimulated by 100 μM Ni2+. At the same time, Ni2+ did not affect the state 3 and the 2,4-dinitrophenol-stimulated respiration of RHM. Our findings allow suggesting that the Ni2+-induced increase in the cardiac contraction amplitude is affected by energy state of the rat cardiomyocytic mitochondria.
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